Non-neuronal Adenosine Triphosphate (atp) Release and Immunohistochemical Examination of Bladder in Hydrochloric Acid (hcl)- Induced Cystitis Rats
نویسندگان
چکیده
Hypothesis / aims of study Interstitial cystitis (IC) is one of chronic diseases of the urinary bladder characterized by urinary frequency, urgency, and pelvic pain associated with bladder distention. Although the symptoms and specific findings during cystoscopy are obvious, the etiology remains unclear. Recently, it has been suggested that adenosine triphosphate (ATP) releases from the bladder mucosa are related to the pathophysiology of IC. And, it has been reported that the histological characteristics of the bladder induced by hydrochloric acid (HCl) instillation is similar to that of clinical IC. Therefore, the present study was performed to investigate bladder function, non-neuronal ATP release from bladder mucosa, and immunohistological change of bladder in HCl-induced cystitis rats.
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